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Kratom Addiction: DSM-5 Criteria & What Treatment Shows

Written by Sunflower Addiction Treatment | Apr 8, 2026 3:01:12 PM

The question sounds simple. The answer is anything but. Kratom sits in a space that most people find genuinely confusing: it is legal, widely available, often framed as natural or plant-based, and used by millions of Americans for pain, anxiety, and even as a self-directed strategy for managing opioid withdrawal. But clinical evidence is telling a different story than the marketing, and what treatment providers are seeing in practice is worth understanding clearly.

What the Research Actually Shows

Yes, kratom can cause addiction. And the clinical criteria used to define it are the same ones applied to every other substance use disorder.

A 2024 study published in Drug and Alcohol Dependence, conducted by researchers at NIDA and the National Institutes of Health, enrolled nearly 400 active kratom users and assessed them against DSM-5 criteria for substance use disorder. Substance use disorder for kratom was primarily mild to moderate in frequent users, and kratom physical dependence was common, though largely without psychosocial impairment.

A separate NIH-supported study found something more striking: of respondents with at least one lifetime regular use of kratom, approximately one-third currently met DSM-derived criteria for kratom use disorder.

One in three. Among people who had used kratom regularly.

That is not a fringe outcome. That is a signal that something clinically significant is happening at a population level, in a product category that most consumers still associate with supplements and herbal wellness.

How Kratom Addiction Presents

The clinical picture of kratom use disorder has a specific shape, and it differs somewhat from what most clinicians associate with opioid use disorder. According to a 2024 review published in Current Psychiatry Reports by researchers at NIDA's Translational Addiction Medicine Branch, individuals meeting DSM-5 kratom use disorder criteria typically do so via tolerance and withdrawal, using more than intended, and craving, not functional or psychosocial disruption, which occurs rarely.

What this means practically is that someone can meet the criteria for a substance use disorder while continuing to show up to work, maintain relationships, and function in ways that make the problem invisible to everyone around them, including sometimes themselves. The dependence is real. The disruption is internalized.

The withdrawal symptoms, when they come, are recognizable to anyone familiar with opioid withdrawal. The NIH study found that most respondents reported having experienced a kratom withdrawal syndrome of mild to moderate severity that in many respects resembled opioid withdrawal. Muscle aches, insomnia, anxiety, gastrointestinal distress, and persistent cravings are the hallmarks. For people using concentrated 7-OH products specifically, the severity of this syndrome intensifies considerably, because the pharmacological profile shifts from kratom use disorder into something clinicians are increasingly treating as opioid use disorder outright. Sunflower Recovery's clinical team works directly with patients presenting this full spectrum of severity.

The 7-OH Distinction Matters Enormously

Not all kratom use carries equal risk, and this is where the clinical conversation has to be precise. According to Johns Hopkins Medicine, patients who use kratom whole-leaf or extract products but who also use 7-OH products might reasonably be considered as having both kratom use disorder and opioid use disorder, as 7-OH is a highly selective mu-opioid receptor agonist with binding affinity 14 to 22 times more potent than morphine.

That distinction changes the treatment picture significantly. Someone using traditional kratom powder is in a different clinical category than someone who has been using concentrated 7-OH shots daily for months. Clinicians need to assess which type of product a patient has actually been using, how frequently, and at what doses, before any treatment planning can be meaningful. For a deeper look at 7-OH specifically, Sunflower's recovery blog covers the physiology and withdrawal profile of concentrated 7-OH products in detail.

What Treatment Looks Like at Sunflower Recovery

The evidence base for treating kratom use disorder is still developing, but the clinical direction is clear. The Current Psychiatry Reports review notes that most clinicians who use medication to treat patients with isolated kratom use disorder select buprenorphine formulations, and that treatment must be individualized for each patient based on their specific preferences, characteristics, and comorbidities.

At Sunflower Recovery in Osawatomie, Kansas, treatment for kratom and 7-OH dependence is not approached with a one-size framework. The intake process evaluates what products were being used, the history and context of that use, the presence of co-occurring conditions like chronic pain or anxiety disorders that may have driven the use in the first place, and what level of care the clinical picture actually warrants.

For some patients, that means medical detox followed by residential treatment. For others, a step directly into a Partial Hospitalization or Intensive Outpatient Program is appropriate. The goal in every case is to address not just the kratom dependence but the underlying conditions that made it feel necessary, because those conditions do not resolve when the substance is removed. Sunflower's approach to treating addiction is built around that broader picture.

The short answer to whether kratom can cause addiction is yes. The more useful answer is that it depends heavily on what someone has been using, for how long, and at what potency. The clinical community now has tools to assess that with real precision, and Sunflower Recovery is equipped to use them.

Concerned about kratom or 7-OH use? Call Sunflower Recovery or verify your insurance online. Our team will help you understand what level of care is right for you.